こんな感じかな。

Function IsNone(hoge) as Boolean
  Select case True
    Case IsNull(hoge)
      IsNone = True
    Case IsEmpty(hoge)
      IsNone = True     
    Case hoge is Nothing
      IsNone = True
    Case hoge = ""
      IsNone = True
    Case hoge = vbnullstring
      IsNone = True
    Case Else
      IsNone = False
  End Select
End Function