ロンドンの研究チームが特定した“幸福の遺伝子”「5-HTT遺伝子」 http://うつ病原因対策.jp/entry37.html つまりドーパミン、アドレナリンを押さえるセロトニンがじゃぶじゃぶだと抑制が聞きやすい それが幸福の遺伝子となり、セロトニンがでないでいるとドーパミンが押さえられない 思い込みや怒りが押さえられない状態となる 0130優しい名無しさん2017/11/30(木) 06:21:29.28ID:JzgJtwZLhttps://vitaminj.tokyo/archives/5284 あと同じようなのがCOMT遺伝子 0131優しい名無しさん2017/11/30(木) 06:29:18.31ID:JzgJtwZL 不安障害や感情障害に関連しないから恐らく違う https://www.ncbi.nlm.nih.gov/pubmed/24842237 We were not able to find any associations between 5-HTTLPR and anxiety-related phenotypes in both case-control and trio analyses.
http://www.nature.com/articles/4000936 5-HTTLPR allele frequencies were not significantly different between controls and bipolars, major depressives, schizophrenics, delusionals and psychotic NOS; genotype analysis also did not show any association. The analysis of symptomatology did not show significant differences.
>However, 46% of known serial killers have not undergone injuries to their frontal lobes. シリアルキラーの46%は前頭葉の損傷を伴っていない 0139優しい名無しさん2017/11/30(木) 09:03:17.69ID:JzgJtwZL 酒鬼薔薇なんかも本なんかの情報読む限り、性的サディズム要素を持ってるがこういう 恐怖感情不安感情の不具合などは伴ってないと感じる だとしたらサイコパス的な生活様式、パターンがあらわれないのだから当然診断からはもれる 結局診断によるわけだから つまりサイコパスではない、と 0140優しい名無しさん2017/11/30(木) 11:27:41.10ID:3ogIRAt3>>138は日本語が理解できないことがわかった。 半島にお帰り。サラムニダ?? 0141優しい名無しさん2017/11/30(木) 19:54:50.81ID:JzgJtwZL だからまず精神疾患型の遺伝子があって、(MAOAと書くと色々うるさいので)
前スレ464 >http://www.psychiatrictimes.com/special-reports/neurobiology-borderline-personality-disorder >Volume. A meta-analysis of brain volume?which comprised 281 persons with BPD >and 293 healthy controls?and 19 imaging studies noted left amygdala and right >hippocampus gray volume decreases in persons with BPD.1 >左扁桃体と右海馬の容量縮小 >共通だろ >つまり結論づいてんだよ >反社会性になくてサイコパスにあるもの >それは自傷行為や依存症や不眠を起こす遺伝子
前スレ467 >>>464引用部分は、以下のように続く >Volume studies in adolescent-onset BPD populations also exist but are limited by small sample size, >discrepant imaging techniques, and highly comorbid presentations. They do not reproduce the volume differences reported in studies of adult BPD. (中略) >Another meta-analysis showed heightened activity in the insula and less activation in the subgenual anterior cingulate cortex in persons with BPD but did not find amygdala hyperactivity. >Conflicting amygdala results are believed to result from the medication status of research participants because psychoactive drugs attenuate limbic activity. >Pharmacologic probes have also shown decreased metabolic activity in the anterior cingulate cortex and orbital frontal cortex in response >to serotonergic challenge in impulsive-aggressive and affectively unstable BPD populations, >and decreased coupling of resting metabolism between the orbital frontal cortex and the ventral anterior cingulate cortex has been reported. >論文でしばしば使われる手法。異なる2つの結果を示して「現段階ではよくわかりません」を表している 0155優しい名無しさん2017/12/01(金) 16:02:45.95ID:08D+cloc 5-HTTもmaoaと同じで多形遺伝子ならP値の算出の仕方もおなじなんかな。 その文献中で言及されてる? 0156優しい名無しさん2017/12/01(金) 17:06:25.05ID:08D+cloc 結局繰り返しの多いグループHと少ないグループLで分けるしかないのか。 とりあえずP値だけなら Monoamine oxidase A gene (MAOA) predicts behaivioral aggression following provocation http://m.pnas.org/content/106/7/2118.long Our analysis drops 8 subjects that in a postexperiment survey expressed disbelief in whether they were actually forcing other subjects to eat hot sauce [although our results change little whether we include these subjects or not (SI Text??Section S5 and??Table s2)]. We find clear support for our initial hypothesis that high take subjects behave in an aggressive manner toward their opponent more frequently, and with greater intensity, than low take ones. Because our design randomized the amount taken in each round, approximately half the people in each round had 80% of their earnings taken whereas the other half had 20% taken. Because of the nonnormal distributions of our data we use Wilcoxon rank-sum tests. We also report one-tailed test statistics in keeping with our directional hypotheses. Pooling across all 4 rounds of the experiment, subjects demonstrated higher levels of behavioral aggression when 80% was taken than when 20% was taken (n??= 292, Z = ??6.16,??P??< 0.001,?Fig. 1). A test of proportions also revealed that subjects were more likely to try to harm their adversary by some amount (rather than nothing) when 80% was taken than 20% (66% versus 39%,??n??= 292, Z = ??4.70,??P??< 0.001). We also observed highly significant differences in the same direction when analyzing each of the rounds separately and when we include observations only of the??firsttime someone experienced 20% or 80% taken from them (SI Text??Section S6). 0157優しい名無しさん2017/12/01(金) 23:08:59.48ID:V+5skHXC>>156 で、 MAOA-Lの染色体領域と対立遺伝子の配列、および MAOA-Hの染色体領域と対立遺伝子の配列を知りたいのだが リンク先には一切説明が無かったので答えて欲しい